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Ketoconazole 200 mg Tablets – 100ct
Prescription Required

$69.09

Orally administered systemic anti-fungal agent.

Quantity:

Description

Ketoconazole 200 mg tablets is an orally administered systemic anti-fungal agent used in the treatment of selected fungal infections in dogs and cats.

Additional information

Weight 0.138 lbs
Dimensions 3.5 x 1.5 x 1.5 in

More Details

This medication requires a prescription from your veterinarian.

Ketoconazole, USP is a synthetic broad-spectrum antifungal agent. Each tablet, for oral administration, contains 200 mg ketoconazole, USP base. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone.

Ketoconazole is an anti-fungal agent labeled for use in humans that can be used extra-label for treatment of fungal infections in animals.

Formulations

Use as directed by your veterinarian.

Administration

Ketoconazole 200mg tablets are available in bottles of 100 count and 500 count.

Precautions

Contraindications / Precautions / Warnings

Ketoconazole is contraindicated in patients with known hypersensitivity to it. It should be used with caution in patients with hepatic disease or thrombocytopenia. Because of its effects on cortisol synthesis, it should be used with caution in dogs undergoing stressful events (eg, surgery, trauma, critical illness).

Use in cats is controversial as anorexia, weight loss, and hepatotoxic effects are possible.

There are many potential drug interactions possible with ketoconazole. It is a potent inhibitor of CYP3A12 (and possibly other isoenzymes) and can inhibit P-glycoprotein.

Long-term use of ketoconazole has been associated with development of cataracts.

Adverse Effects

Gastrointestinal signs of anorexia, vomiting, and/or diarrhea and weight loss are the most common adverse effects seen with ketoconazole therapy and are more prevalent in cats. Dividing the dose and/or giving it with meals may minimize gastrointestinal side effects. Appetite stimulants such as oxazepam or cyproheptadine may also be of benefit in cats.

Hepatic toxicity consisting of cholangiohepatitis and increased liver enzymes has been reported with ketoconazole, and may be either idiosyncratic in nature or a dose-related phenomenon. Cats may be more prone to developing hepatotoxicity than dogs. While liver enzymes should be monitored during therapy, an increase does not necessarily mandate dosage reduction or discontinuation unless concomitant anorexia, vomiting, diarrhea, or abdominal pain is present. Thrombocytopenia has also been reported with ketoconazole therapy, but is rarely encountered. A reversible lightening of haircoat may also occur in patients treated with ketoconazole. Cataracts in dogs, anecdotally attributed to ketoconazole therapy has been reported.

Ketoconazole has a transient dose-related suppressant effect on gonadal and adrenal steroid synthesis. Doses as low as 10 mg/kg depressed serum testosterone levels in dogs within 3-4 hours after dosing, but levels returned to normal within 10 hours. Doses of 30 mg/kg/day have been demonstrated to suppress serum cortisol levels in dogs with hyperadrenocorticism. Dogs undergoing high dose antifungal therapy may need additional glucocorticoid support during periods of acute stress.

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