Furosemide 1% Syrup, 60ml
Prescription Required

Generic name: Furosemide (except in United Kingdom-frusemide). Chemical name: 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

ACTIONS

The therapeutic efficacy of Furosemide Syrup 1% is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule, but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug’s rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimizes the possibility of lipid accumulation in tissues and organs or of crystalluria. Furosemide Syrup 1% has no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity in the presence of either acidosis or alkalosis. ^1-7

INDICATIONS

DOG

Furosemide Syrup 1% is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema.

Furosemide Syrup 1% is indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. The continued use of heart stimulants, such as digitalis or its glycosides, is indicated in cases of edema involving cardiac insufficiency.

CONTRAINDICATIONS-PRECAUTIONS

Furosemide Syrup 1% is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patients’ needs. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered. Early signs of electrolyte imbalance are: Increased thirst, lethargy, drowsiness or restlessness, fatigue, oliguria, gastrointestinal disturbances and tachycardia. Special attention should be given to potassium levels.

Furosemide Syrup 1% may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency. ^10-14

Although diabetes mellitus is a rarely reported disease in animals, active or latent diabetes mellitus may on rare occasions be exacerbated by Furosemide Syrup 1%. While it has not been reported in animals, the use of high doses of salicylates, as in rheumatic diseases, in conjunction with Furosemide Syrup 1% may result in salicylate toxicity because of competition for renal excretory sites. Electrolyte balance should be monitored prior to surgery in patients receiving Furosemide Syrup 1%. Imbalances must be corrected by administration of suitable fluid therapy.

Furosemide Syrup 1% is contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma; therefore, observation during period of therapy is necessary. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium depleting steroids.

WARNINGS

Furosemide Syrup 1% is a highly effective diuretic and, as with any diuretic, if given in excessive amounts may lead to excessive diuresis that could result in electrolyte imbalance, dehydration and reduction of plasma volume, enhancing the risk of circulatory collapse, thrombosis, and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids.

It is important to correct potassium deficiency with dietary supplementation. Caution should be exercised in prescribing enteric-coated potassium tablets.

There have been several reports in human literature, published and unpublished, concerning nonspecific small-bowel lesions consisting of stenosis, with or without ulceration, associated with the administration of enteric-coated thiazides with potassium salts. These lesions may occur with enteric-coated potassium tablets alone or when they are used with non-enteric-coated thiazides, or certain other oral diuretics. These small-bowel lesions may have caused obstruction, hemorrhage, and perforation. Surgery was frequently required, and deaths have occurred. Available information tends to implicate enteric-coated potassium salts, although lesions of this type also occur spontaneously. Therefore, coated potassium-containing formulations should be administered only when indicated, and should be discontinued immediately if abdominal pain, distension, nausea, vomiting, or gastrointestinal bleeding occurs. Human patients with known sulfonamide sensitivity may show allergic reactions to Furosemide Syrup 1%; however, these reactions have not been reported in animals.

Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Furosemide Syrup 1% and it is advisable to discontinue Furosemide Syrup 1% for one day prior to any elective surgery.

DOSAGE AND ADMINISTRATION

The usual dose of Furosemide Syrup 1% is 1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). Administer once or twice daily at 6- to 8-hour intervals orally. A prompt diuresis usually ensues from the initial treatment. Diuresis may be initiated by the parenteral administration of furosemide injection and then maintained by oral administration.

The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1 mg/lb body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition of the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dosage schedule, i.e., every other day or 2 to 4 consecutive days weekly.

Diuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO₂ and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.

DOSAGE

ORAL:

DOG-Syrup 1%

One (1) to two (2) mL (10 to 20 mg furosemide) per 10 lb body weight (approximately 2.5 to 5 mg/kg).

Administer once or twice daily, permitting a 6- to 8-hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg/lb body weight as recommended in preceding paragraphs, “DOSAGE AND ADMINISTRATION”.

HOW SUPPLIED

Oral:

Furosemide Syrup 1% (10 mg/mL), available in 60 mL bottles with calibrated dropper.

TOXICOLOGY

Acute Toxicity:

The following table illustrates low acute toxicity of Furosemide Syrup 1% in three different species. (Two values indicate two different studies.)

LD₅₀ of Furosemide Syrup 1% in mg/kg body weight

*NOTE: The lower oral LD₅₀ value for the rat was obtained in a group of fasted animals; the higher figure is from a study performed on fed rats.

Toxic doses lead to convulsions, ataxia, paralysis and collapse. Animals surviving toxic doses may become dehydrated and depleted of electrolytes due to the massive diuresis and saluresis.

Chronic Toxicity:

Chronic toxicity studies with Furosemide Syrup 1% were done in a one-year study in rats and dogs. In a one-year study in rats, renal tubular degeneration occurred with all doses higher than 50 mg/kg. A six-month study in dogs revealed calcification and scarring of the renal parenchyma at all doses above 10 mg/kg.

Reproductive Studies:

Reproductive studies were conducted in mice, rats and rabbits. Only in rabbits administered high doses (equivalent to 10 to 25 times the recommended average dose of 2 mg/kg for dogs, horses and cattle) of furosemide during the second trimester did unexplained maternal deaths and abortions occur. Furosemide Syrup 1% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The effects of alcohol administered to pregnant Beagles at 3 and at 3.6 gms/kg/day throughout gestation suggests that alcohol may reduce the number of offspring per litter, the birth weight per pup and increase the incidence of stillbirths. There have been no studies conducted in pregnant dogs administered alcohol at levels found in Furosemide Syrup 1%.

REFERENCES

1. Timmerman RJ, Springman FR, Thomas RK: Evaluation of furosemide, a new diuretic agent. Curr Ther Res 6:88-94, 1964.

2. Muschaweck R, Hajdu P: The saluretic action of 4-Chloro-N-(2-furylmethyl)-5-sulfamyl-anthranilic acid. (Die salidiuretische Wirksamkeit der Chlor-N-(2-furylmethyl)-5-sulfamyl-anthranilsaure.) Arzneim Forsch 14:44-47, 1964.

3. Suki W, Rector FC Jr, Seldin DW: The site of action of furosemide and other sulfonamide diuretics in the dog. J Clin Invest 44:1458-1469, 1965.

4. Deetjen P: Micropuncture studies of the action of furosemide. (Mikropunktionsuntersuchungen zur Wirkung von Furosemid.) Pfluegers Arch 284:184-190, 1965.

5. Berman LB, Ebrahimi A: Experiences with furosemide in renal disease. Proc Soc Exp Biol Med 188:333-336, 1965.

6. Schmidt HAE: Animal experiments with S35 tagged Lasix^® in canine and ovine. Internal report, Radiochemical Pharmacological Laboratory, Frankfurt, West Germany, Farbwerke Hoechst, 1964.

7. Haeussler A, Hajdu P: Methods of biological identification and results of studies on absorption, elimination, and metabolism. Internal report, Research Laboratories, Frankfurt, West Germany, Farbwerke Hoechst.

8. Wilson AF, Simmons DH: Diuretic action in hypochloremic dogs. Clin Res 14:158, 1966.

9. Hook JB, Williamson HE: Influence of probenecid and alterations in acid-base balance of the saluretic activity of furosemide. J Pharmacol Exp Ther 149:404-408, 1965.

10. Antoniou LD, et al: Sodium and calcium transport in the kidney. Clin Res 15:476, 1967.

11. Duarte CG: Effects of furosemide (F) and ethacrynic acid (ETA) on the renal clearance of phosphate (Cp), ultra-filterable calcium (CUf-Ca) and magnesium (CUfMg). Clin Res 15:357, 1967.

12. Duarte CG: Effects of ethacrynic acid and furosemide on urinary calcium, phosphate and magnesium. Metabolism 17:867-876, 1968.

13. Nielsen SP, Andersen O, Steven KE: Magnesium and calcium metabolism during prolonged furosemide (Lasix^®) administration to normal rats. Acta Pharmacol Toxicol 27:469-479, 1969.

14. Reimold EW: The effect of furosemide on hypercalcemia due to dihydrotachysterol. Metabolism 21:593-598, 1972.

CAUTION: Keep container tightly closed. Discard opened bottle after 60 days. Protect from light.

STORAGE: Store at controlled room temperature (59°-86°F).

For animal use only.

Keep out of reach of children.

Rev. 02-13

Manufactured by: First Priority, Inc., Elgin, IL 60123-1146

Distributed by: MWI, Boise, ID 83705

www.VetOne.net

ANADA#200-373, Approved by FDA

CPN: 1315088.1