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Trilostane is an FDA approved medication used to treat Cushing’s disease (hyperadrenocorticism) in dogs and cats, and Alopecia X in dogs. It decreases the production of the cortisol hormone by blocking the enzyme needed to make it in the adrenal glands. Trilostane is a synthetic enzyme drug that does not cure the condition but can help manage it.
Dogs usually respond to this medication therapy within two to four weeks. Your veterinarian will monitor your dog closely, especially at the start of the treatment.
Trilostane is also used to treat Cushing’s disease in cats. While this disease is not common in cats, those with Cushing’s disease may also have underlying diabetes mellitus. Trilostane has not been proven to change their insulin needs.
Trilostane can also be used for the treatment of pituitary pars intermedia dysfunction (PPID) in horses.
Help treat your pets Cushing disease and give them a healthier and improved quality of life with Trilostane. All our medications are made in our state-of-the-art pharmacy lab in Arizona, USA.
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Trilostane compounded in cod liver oil is given by mouth in liquid form daily with food for improved bioavailability. This medication should start to take effect within 1 to 2 days.
This medication should be given just as your veterinarian prescribes. It must be measured carefully, and it's best to use the syringe provided to ensure you are able to give the proper dosage required. After dosing your pet, rinse and dry the syringe, and screw the cap tightly onto the bottle. We recommend washing hands after administering the medication. If you are pregnant or trying to become pregnant, do not handle this medication.
Trilostane is a prescription medication for treating Cushing’s disease in cats and dogs. If you have difficulty giving it to your pet, contact your veterinarian for some helpful tips. We recommend washing your hands with soap and water after handling any medication.
Possible Side Effects
Trilostane compounded in cod liver oil is generally safe, however, the most common side effects can include diarrhea, vomiting, lethargy, mild electrolyte abnormalities, or lack of appetite during the first few days of therapy secondary to steroid withdrawal. These side effects are usually mild.
Hypoadrenocorticism can happen and is generally reversible once the medication is stopped, however in some cases, adrenal gland damage can occur in dogs.
In cats, side effects can include anorexia, lethargy, and dulled mental activity.
A life-threatening condition, called an Addisonian crisis, can occur while your pet is using this medication. Your pet should be monitored closely for diarrhea, vomiting, lethargy, shaking, weakness, collapse, and increased drinking or urination. Contact your veterinarian immediately if these side effects or allergic reactions continue or become more severe.
Drug & Food Interactions
Drug Interactions: If your pet is on any of the following medications you should use trilostane with caution:
- Ace Inhibitors :(e.g. benazepril, enalapril): When combined may increase risk for hyperkalemia.
- Ketoconazole: When combined may potentiate the effects of trilostane and lead to hypoadrenocorticism.
- Mitotane:When combined may potentiate the effects of trilostane and lead to hypoadrenocorticism. Wait at least 1 month after discontinuing mitotane before initiating trilostane.
- Potassium-Sparing Diuretics(e.g. spironolactone): When combined may increase risk for hyperkalemia.
- Potassium-Supplements: High Potassium Foods: When combined may increase risk for hyperkalemia.
Trilostane should not be given to pets that are hypersensitive or allergic to it. It should not be given to animals that are pregnant. Trilostane is metabolized by the liver and should be used with caution in pets with kidney or liver disease, in animals that are anemic, or in animals that are nursing.
Trilostane can affect the levels of other hormones produced in the adrenal gland. Some dogs can be at an increased risk for metabolic problems including dehydration, weakness, and abnormal serum electrolyte levels.
Keep this medication out of reach of children. Trilostane is a prescription medication and should be used based on your veterinarian’s directions.
Your veterinarian will likely monitor your pet for any side effects. Laboratory tests and Adrenocorticotropic hormone (ACTH) stimulation tests will be needed to monitor for adverse effects, and efficacy of the medication.
Your veterinarian will need to see your pet regularly to make sure that the medication is working properly, it is important to attend all follow up visits.
Trilostane compounded in cod liver oil is given to your pet by mouth with food daily and should take effect in about 1 to 2 days. Exact instructions will be prescribed by your veterinarian.
Trilostane compounded in cod liver oil should be stored at room temperatures from 68° - 77°F with the cap tightly closed, and away from light, moisture, heat, or humidity.
Trilostane compounded in cod liver oil should be given orally as prescribed by your veterinarian.
It is important to keep on schedule and not miss a dose. Do not double the next dose if this happens, two doses should never be given at the same time.
What if I miss giving my pet a dose? If you miss a dose, give the next dose as soon as possible. If it is almost time for the following dose, then continue with the next scheduled one and skip the missed dose. Do not give a double dose to catch up or make up for a missed dose.
What is Trilostane?
Trilostane is the generic medication for the brand name Vetoryl. It is used for the treatment of hyperadrenocorticism also known as Cushing's disease, in dogs and cats, and Alopecia X in dogs. It is available in tablet form or compounded liquid.
What is Trilostane for dogs?
Trilostane is used to treat dogs and cats with Cushing’s disease. It is an FDA-approved medication that tends to have fewer side effects than other drugs. Trilostane prevents the adrenal glands from making cortisol by blocking the enzyme (protein) needed to make it in the adrenal glands.
How long does it take for trilostane to work?
Trilostane can start to show some effects within 1-2 days, but its full effects can take 2-4 weeks.
Can trilostane hurt a dog?
Trilostane cannot hurt a dog, but it can cause various side effects. Pet owners should monitor all adverse effects such as diarrhea, vomiting, lethargy, mild electrolyte abnormalities, and lack of appetite. If you notice any of these serious side effects, contact your veterinarian immediately.
What is the trilostane dose for dogs?
Trilostane is dosed once or twice daily by mouth with food, in the form of a capsule or compounded liquid. The exact dosage for your dog or cat will be prescribed by your veterinarian.
Where to buy trilostane for dogs?
You can buy trilostane for dogs and cats online at ExpressVet Pharmacy. Once authorized by your vet, your prescription will be conveniently shipped within 1 to 2 business days.
Do I need a prescription for trilostane?
Yes, a prescription is required for trilostane and your veterinarian will be able to provide it for your pet.
What are the side effects of trilostane in dogs?
Adverse effects in dogs can include diarrhea, vomiting, lethargy, mild electrolyte abnormalities (e.g. hyponatremia, hyperkalemia), lack of appetite during the first few days of therapy secondary to steroid withdrawal. These side effects are usually mild.
What if my pet overdoses?
If you know or suspect that your pet experienced an overdose, call veterinary services immediately or a 24-hour poison consultation center should be contacted. Signs of an overdose can include panting, vomiting, tremors, vocalization, and increased heart rate.
What is compounding?
Compounding is a method of preparing individualized prescription medications by licensed pharmacists. Compounding allows the practitioner, the pharmacist, and the pet owner to collaborate to create custom dosages, flavors, and dosage forms for pets to easily, safely, and effectively take their medication. Often pet owners struggle to give oral tablets which is why ExpressVet offers compounded oral liquids, transdermal gels, capsules, and treats to make taking care of your pet easy.
How do I order a compounded prescription medication for my pet?
- Sign in to your existing ExpressVet account or create a new account.
- Select the item or item(s) you are requesting and add to your cart.
- Add your pet’s information and your vet’s information. If you are a returning customer, you will see your previous choices available or you can add them as new.
- Let us know if you want us to request a prescription from your veterinarian, or if you would like to mail in a prescription.
- Complete your billing, shipping, and payment information at checkout to complete your order.
Do all compounded medications require a prescription?
Yes, all compounded medications require a prescription. Express Vet Pharmacy is happy to request a prescription order from your veterinarian, but all prescription orders must be accompanied by a patient-specific prescription from a licensed veterinarian before an order can be shipped out.
Where is Express Vet licensed to dispense veterinary prescription medications?
We are licensed in the following states. Alaska (AK), Arizona (AZ), California (CA), Colorado (CO), Connecticut (CT), Delaware (DE), Florida (FL), Hawaii (HI), Illinois (IL), Iowa (IA), Kansas (KS), Kentucky (KY), Massachusetts (MA), Michigan (MI), Minnesota (MN), Missouri (MO), Montana (MT), Nebraska (NE), New Jersey (NJ), New Mexico (NM), New York (NY), North Dakota (ND), Ohio (OH) (no compounds), Oregon (OR), Pennsylvania (PA), Rhode Island (RI), South Dakota (SD), Tennessee (TN), Texas (TX), Utah (UT), Vermont (VT), Virginia (VA), Washington (WA), West Virginia (WV), and Wisconsin (WI)
Where does ExpressVet source the ingredients for compounding?
All ingredients for compounding are from FDA registered manufacturers and distributors.
How long does it take to process my prescription after the pharmacy receives it?
Once the pharmacy receives authorization to dispense from your veterinarian, compounded medications are prepared and shipped out within 1 to 2 business days.