Zonisamide Compounded Oral Liquid for Dogs and Cats
Zonisamide Compounded Oral Liquid for Dogs and Cats

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Zonisamide Compounded Oral Liquid for Dogs and Cats

Regular price $51.95 Sale price $45.00 Save $6.95

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This item requires prescription approval. Details

We DO NOT ship Prescriptions to the following states: Idaho, Oklahoma, Arkansas, Louisiana, Mississippi, Alabama, Maryland, Washington DC, Georgia, South Carolina, North Carolina, New Hampshire, Maine, Nevada.
DO NOT place an order if you plan to ship to the states listed, if you do your order will be canceled automatically.


Zonisamide is an antiseizure (anticonvulsant) medication used as therapy for epilepsy or as an add-on drug for hard to control seizures in dogs and cats. Controlling seizures in dogs and cats can often be done with one medication, however, some are more difficult to control than others. When this happens, your veterinarian may prescribe a separate medication or a supplement to be taken with phenobarbital such as zonisamide. This drug is usually taken once or twice daily.
Seizures are also known as a fit or convulsion, is a temporary involuntary chain of movements, and uncontrollable actions of muscle activity and behavior in your pet. This is caused by a disruption in the brain function. If a seizure lasts for more than 3-5 minutes they should be seen by a veterinarian.
Help control your pets blood seizures and epilepsy and give them a healthier and improved quality of life with zonisamide. All our medications are made in our state-of-the-art pharmacy lab in Arizona, USA.
Purchasing affordable pet medications online has never been easier! ExpressVet offers the largest selection of pet medications on planet earth. If you can't find it here, let us know and we'll get it for you! Transform your pet's life with the best pet medications available on the market today.
When it comes to something as important as your pets, you want the best medication possible without breaking the bank. When you buy ExpressVet's compounded medications, you get better value and happy pets!


Zonisamide compounded oral liquid is given by mouth in liquid form once daily with or without food. If your pet vomits after dosing it on an empty stomach, try giving future doses with food. The effects should be noticeable within 1 to 2 days. Do not stop this medication suddenly or seizures may occur.
This medication should be given just as your veterinarian prescribes. It must be measured carefully, and it's best to use the syringe provided to ensure you are able to give the proper dosage required. After dosing your pet, rinse and dry the syringe, and screw the cap tightly onto the bottle.
Zonisamide is a prescription medication for treating seizures and epilepsy in cats and dogs. If you have difficulty giving it to your pet, contact your veterinarian for some helpful tips. We recommend washing your hands with soap and water after handling any medication.

Possible Side Effects

Zonisamide compounded oral liquid is generally safe, however, the most common side effects in dogs can include drowsiness, incoordination when walking, vomiting, and lack of appetite.
Some rare side effects can include aggression, liver disease or urinary stones. If your pet stops eating, develops yellow skin color, gums, or white eyes contact your veterinarian immediately.
In cats, common side effects may include lack of appetite, vomiting, diarrhea, incoordination and sleepiness.
This medication lasts for approximately 24-48 hours in dogs and cats, however, side effects may last for 1 or 2 days after the medication is discontinued.
Contact your veterinarian immediately if these side effects continue or become more severe.

Drug & Food Interactions

Drug Interactions: If your pet is on any of the following medications you should use zonisamide with caution:

  • CYP3A Inducers:(e.g. carbamazepine, dexamethasone, rifampin) When combined may shorten the half-life of zonisamide and require dose adjustment.
  • Carbonic Anhydrase Inhibitors:(CAIS, e.g. acetazolamide) When used at the same time with carbonic anhydrase inhibitors, it may increase the risk for metabolic acidosis and kidney stone formation.
  • Phenobarbital: When combined with phenobarbital, higher doses of zonisamide may be required or phenobarbital doses might need to be decreased.

It is important to tell your veterinarian about any medications, supplements, vitamins, or supplements that your pet is taking.


Zonisamide should not be given to pets that are hypersensitive or allergic to it. It should not be used in animals that are pregnant, breeding or have liver disease. It should be used with caution in pets that are nursing.


Your veterinarian will likely monitor your pet for acceptable seizure control, zonisamide blood levels, CBC and serum chemistry.

Your veterinarian will need to see your pet regularly to make sure that the medication is working properly, it is important to attend all follow up visits.

If your pet stops eating, becomes extremely lethargic, appears to have a yellow color skin tone, or whites of the eyes, contact your veterinarian immediately. It is important to track the frequency of seizures while your pet is taking this medication to monitor how well it is working.

Active Ingredients



Zonisamide compounded oral liquid is given to your pet by mouth with or without food daily. If vomiting occurs when given on an empty stomach, give future doses with food. Exact instructions will be prescribed by your veterinarian.

Storage Instructions

Zonisamide compounded oral liquid should be stored at room temperatures from 68° - 77°F with the cap tightly closed, and away from light, moisture, heat, or humidity.


Zonisamide compounded oral liquid should be given orally, once, or twice a day with or without food. The exact zonisamide dosage for dogs and cats will be prescribed by your veterinarian.

It is important to keep on schedule and not miss a dose. If a dose is missed your pets blood pressure can suddenly rise causing an increased risk for seizures. Do not double the next dose if this happens, two doses should never be given at the same time.

What if I miss giving my pet a dose? If you miss a dose, give the next dose as soon as possible. If it is almost time for the following dose, then continue with the next scheduled one and skip the missed dose. Do not give a double dose to catch up or make up for a missed dose.


What is Zonisamide?

Zonisamide is the generic medication for the brand name Zonegran. It is used with other medications to control and prevent seizures or epilepsy, and is available in tablet form or compounded liquid.

What is zonisamide for dogs?

Zonisamide is an anticonvulsant (antiseizure) medication used to treat dogs and cats that have been diagnosed with a seizure disorder such as epilepsy.

How long does it take for zonisamide to work?

Zonisamide is dosed by mouth as a compounded liquid or capsule. It can be given with or without food and should start working within 1-2 days in animals.

Is zonisamide safe for dogs?

Yes, it is. Zonisamide is safe for use in both dogs and cats and can help control seizures. This medication is usually taken twice a day by dogs, and once a day by cats, as a supplement to phenobarbital.

Can zonisamide hurt a dog?

Zonisamide cannot hurt a dog, but it can cause various side effects. Pet owners should monitor all adverse effects such as sedation, vomiting, lack of appetite, and incoordination while walking. If you notice any of these serious side effects, contact your veterinarian immediately.

What is the zonisamide dose for dogs?

Zonisamide is dosed twice a day by mouth in the form of a tablet or compounded liquid. The exact dosage for your dog or cat will be prescribed by your veterinarian.

Where to buy zonisamide for dogs?

You can buy zonisamide for dogs and cats online at ExpressVet Pharmacy. Once ordered your prescription will be conveniently shipped to your home within 1 to 2 business days.

Do I need a prescription for zonisamide?

Yes, a prescription is required for zonisamide, and your veterinarian will be able to provide it for your pet.

What are the side effects of zonisamide in dogs?

Adverse effects in dogs are rare however can include vomiting, loss of appetite, sedation, and incoordination when walking. Some rare side effects can include urinary stones, aggression, or liver disease.

What if my pet overdoses?

If you know or suspect that your pet experienced an overdose, call veterinary services immediately or a 24-hour poison consultation center should be contacted. Signs of an overdose can include panting, vomiting, tremors, vocalization, and increased heart rate.

What is compounding?

Compounding is a method of preparing individualized prescription medications by licensed pharmacists. Compounding allows the practitioner, the pharmacist, and the pet owner to collaborate to create custom dosages, flavors, and dosage forms for pets to easily, safely, and effectively take their medication. Often pet owners struggle to give oral tablets which is why ExpressVet offers compounded oral liquids, transdermal gels, capsules, and treats to make taking care of your pet easy.

How do I order a compounded prescription medication for my pet?

  1. Sign in to your existing ExpressVet account or create a new account.
  2. Select the item or item(s) you are requesting and add to your cart.
  3. Add your pet’s information and your vet’s information. If you are a returning customer, you will see your previous choices available or you can add them as new.
  4. Let us know if you want us to request a prescription from your veterinarian, or if you would like to mail in a prescription.
  5. Complete your billing, shipping, and payment information at checkout to complete your order.

Do all compounded medications require a prescription?

Yes, all compounded medications require a prescription. Express Vet Pharmacy is happy to request a prescription order from your veterinarian, but all prescription orders must be accompanied by a patient-specific prescription from a licensed veterinarian before an order can be shipped out.

Where is Express Vet licensed to dispense veterinary prescription medications?

We are licensed in 38 states. Alaska (AK), Arizona (AZ), California (CA), Colorado (CO), Connecticut (CT), Delaware (DE), Florida (FL), Hawaii (HI), Illinois (IL), Iowa (IA), Kansas (KS), Kentucky (KY), Massachusetts (MA), Michigan (MI), Minnesota (MN), Missouri (MO), Montana (MT), Nebraska (NE), Nevada (NV), New Jersey (NJ), New Mexico (NM), New York (NY), North Dakota (ND), Ohio (OH), Oregon (OR), Pennsylvania (PA), Rhode Island (RI), South Dakota (SD), Tennessee (TN), Texas (TX), Utah (UT), Vermont (VT), Virginia (VA), Washington (WA), West Virginia (WV), and Wisconsin (WI)

Where does ExpressVet source the ingredients for compounding?

All ingredients for compounding are from FDA registered manufacturers and distributors.

How long does it take to process my prescription after the pharmacy receives it?

Once the pharmacy receives authorization to dispense from your veterinarian, compounded medications are prepared and shipped out within 1 to 2 business days.